Non sedating tricyclics
Side effects: Sedation, fatigue, dry mouth, constipation, increased appetite, weight gain.If you stop this medication abruptly, withdrawal symptoms may begin in twenty-four hours, including nausea, tremor, headache, and insomnia. If postural hypotension troubles you, may work more effectively. Therapeutic dose is typically between 50 and 75 mg per day, with some individuals requiring up to 150 mg, based on blood level. Clomipramine (Anafranil) Helps control obsessive-compulsive disorder by reducing the duration and intensity of these symptoms and the corresponding anxiety. Few symptoms should be evident with a gradual decrease in dose. Imipramine causes some jitteriness in about 20 to 25% of subjects, which usually lasts one to three weeks, but can be often avoided by starting with as little as 10 mg before bed. Some patients, especially males, experience reduced sex drive or responsiveness while taking this drug. Less jitteriness than imipramine; less postural hypotension than other tricyclic antidepressants; lightheadedness, mild sedation (sleepiness), weight gain, insomnia, impaired urination and anticholinergic effects (20% experience dry mouth). Some of these side effects will disappear with the passage of time or with a decrease in the dosage.
The anticholinergic effects of dry mouth, blurred vision, constipation, and difficulty in urination; postural hypotension; tachycardia, loss of sex drive; erectile failure; increased sensitivity to the sun; weight gain; sedation (sleepiness); increased sweating.
Possible side effects initially (including insomnia, tremor, or both) may last up to the first two to three weeks of treatment.