Non sedating tricyclics


Whom it may be suitable for: Depression sufferers with fatigue-like symptoms (norepinephrine works on the adrenal system); also a good option when SSRIs don’t work; not ideal for patients with hypertension.Pros: This SSRI has fewer overall side effects than some antidepressants, but the serotonin-related side effects can be powerful. For this reason, the medication trial should probably be initiated with a very low dose -- as little as 10 to 25 milligrams (mg) per day of imipramine, for example. Typically taken in one dose at bedtime, but can be divided. Use during pregnancy or breast-feeding only after approval from your physician. Headache, drowsiness, dizziness, nervousness, trouble sleeping, dry mouth, nausea, vomiting, blurred vision, altered taste, sweating, stomach upset, constipation, loss of appetite, anxiety, or yawning may occur. Some people may experience side effects on dosages as low as 10 mg per day: jitteriness, irritation, unusual energy, and difficulty falling or staying asleep. One-third of panic-prone individuals become jittery and actually experience more anxiety symptoms for the first two to three weeks. The sedating side effects can limit productivity and concentration during the day. Consult your physician before using during pregnancy or breast-feeding. Start at 25 to 75 mg per day and increase over one or two weeks to an average dose of 75 to 150 mg and a maximum dose of 300 mg. Nausea and dizziness can be be common side effects.Pros: A very effective SSRI that can be easier to start and stay on than others.



Side effects: Sedation, fatigue, dry mouth, constipation, increased appetite, weight gain.If you stop this medication abruptly, withdrawal symptoms may begin in twenty-four hours, including nausea, tremor, headache, and insomnia. If postural hypotension troubles you, may work more effectively. Therapeutic dose is typically between 50 and 75 mg per day, with some individuals requiring up to 150 mg, based on blood level. Clomipramine (Anafranil) Helps control obsessive-compulsive disorder by reducing the duration and intensity of these symptoms and the corresponding anxiety. Few symptoms should be evident with a gradual decrease in dose. Imipramine causes some jitteriness in about 20 to 25% of subjects, which usually lasts one to three weeks, but can be often avoided by starting with as little as 10 mg before bed. Some patients, especially males, experience reduced sex drive or responsiveness while taking this drug. Less jitteriness than imipramine; less postural hypotension than other tricyclic antidepressants; lightheadedness, mild sedation (sleepiness), weight gain, insomnia, impaired urination and anticholinergic effects (20% experience dry mouth). Some of these side effects will disappear with the passage of time or with a decrease in the dosage.

The anticholinergic effects of dry mouth, blurred vision, constipation, and difficulty in urination; postural hypotension; tachycardia, loss of sex drive; erectile failure; increased sensitivity to the sun; weight gain; sedation (sleepiness); increased sweating.

Possible side effects initially (including insomnia, tremor, or both) may last up to the first two to three weeks of treatment.